The Massive and Distant Clusters of WISE Survey 2 (MaDCoWS2) is a new survey designed as the successor of the original MaDCoWS survey. MaDCoWS2 improves upon its predecessor by using deeper optical and infrared data and a more powerful detection algorithm (PZWav). As input to the search, MaDCoWS2 use grz photometry from DECaLS in combination with W1 and W2 photometry from the CatWISE2020 catalog to derive the photometric redshifts with full redshift probability distribution functions for WISE-selected galaxies. Cluster candidates are detected using the PZWav algorithm to find three-dimensional galaxy overdensities from the sky positions and photometric redshifts. The second data release of the Massive and Distant Clusters of WISE Survey 2 (MaDCoWS2) expands from the equatorial first data release to most of the Dark Energy Camera Legacy Survey area, covering a total area of 6498 deg^2.