The NEOWISE Post-Cryo Single-exposure Source Database contains 7,337,642,955 measurements of positions and brightness information, uncertainties, time of observation and assorted quality flags made on the individual WISE 7.7s (W1 and W2) Single-exposure images. Because WISE scanned every point on the sky multiple times, the Single-exposure Database contains multiple, independent measurements of objects on the sky. Entries in the Single-exposure Source Database include detections of real astrophysical objects, as well as spurious detections of low SNR noise excursions, transient events such as hot pixels, charged particle strikes and satellite streaks, and image artifacts light from bright sources including the moon. Many of the unreliable detections are flagged in the Single-exposure Database, but they have not been filtered out as they were for the All-Sky Release Source Catalog. Therefore, the Database must be used with caution. Users are strongly encouraged to read the Cautionary Notes before using the Database.