The Spitzer/MIPS 24 and 70 μm imaging of an 11.5 square degree region near the South Ecliptic Pole (SEP) has been carried out in order to complement sub-millimeter wavelength observations (250-500 μm) of the same region of sky taken with the Balloon-borne Large Aperture Sub-millimeter Telescope (BLAST), with the goal of better characterizing the nature of sub-millimeter selected galaxies and their role in galaxy evolution. This field has also been extensively mapped at other wavelengths, and will be imaged from 100-500 μm as part of the Herschel Multi-tiered Extragalactic Survey (HerMES). Source detection and photometry were performed using the APEX software within the MOPEX package. Source candidates with S/N > 5 and reduced chi-squared values less than or equal to three (97% of the sources) are considered reliable detections. The remaining source candidates were then inspected (see Scott et al. 2010 for details) and false positives were removed from the catalog. Some sources in the catalog are flagged as possible false positives; see the status field.