We present the second data release for the GaLactic and Extragalactic All-sky Murchison Widefield Array eXtended (GLEAM-X) survey. This data release is an area of 12892-deg^2^ around the South Galactic Pole region covering 20h40m<=RAM=6h40m, -90{deg}<=Dec<=30{deg}. Observations were taken in 2020 using the Phase-II configuration of the Murchison Widefield Array (MWA) and covering a frequency range of 72-231MHz with twenty frequency bands. We produce a wideband source-finding mosaic over 170-231MHz with a median root mean squared noise of 1.5^+1.5^_-0.5_mJy/beam. We present a catalogue of 624866 components, including 562,302 components which are spectrally fit. This catalogue is 98% complete at 50mJy, and a reliability of 98.7% at a 5{sigma} level, consistent with expectations for this survey. The catalogue is made available via Vizier and the PASA datastore and accompanying mosaics for this data release are made available via AAO Data Central and SkyView.