We report on the results of the Chandra ACIS-I observation on the central region of the Monoceros R2 cloud (Mon R2), a high-mass star-forming region (SFR) at a distance of 830pc. With a deep exposure of ~100ks, we detected 368 X-ray sources, ~80% of which were identified with the near-infrared (NIR) counterparts. We systematically analyzed the spectra and time variability of most of the X-ray emitting sources and provided a comprehensive X-ray source catalog for the first time. Using the J-, H- and K-bands magnitudes of the NIR counterparts, we estimated the evolutionary phase (classical T Tauri stars and weak-lined T Tauri stars) and the mass of the X-ray emitting sources, and analyzed the X-ray properties as a function of the age and mass.