The current generation of (sub)mm-telescopes have allowed molecular line emission to become a major tool for studying the physical, kinematic, and chemical properties of extra-galactic systems, yet exploiting these observations requires a detailed understanding of where emission lines originate within the Milky Way. In this paper, we present 60" (~3pc) resolution observations of many 3mm-band molecular lines across a large map of the W49 massive star-forming region (~100pcx100pc at 11kpc), which were taken as part of the "LEGO" IRAM-30m large project. We find that the spatial extent or brightness of the molecular line transitions are not well correlated with their critical densities, highlighting abundance and optical depth must be considered when estimating line emission characteristics. We explore how the total emission and emission efficiency (i.e. line brightness per H_2_ column density) of the line emission vary as a function of molecular hydrogen column density and dust temperature. We find that there is not a single region of this parameter space responsible for the brightest and most efficiently emitting gas for all species. For example, we find that the HCN transition shows high emission efficiency at high column density (10^22^cm^-2^) and moderate temperatures (35K), whilst e.g. N_2_H^+^ emits most efficiently towards lower temperatures (10^22^cm^-2^; <20K). We determine X_CO(1-0)_~0.3x10^20^cm^-2^/(K.km/s), and {alpha}_HCN(1-0)_~30M_{sun}_/(K.(km/s)pc^2^), which both differ significantly from the commonly adopted values. In all, these results suggest caution in interpreting molecular line emission.