We present the global X-ray properties of the point source population in the grand-design spiral galaxy M101, as seen with XMM-Newton. 108 X-ray sources are detected within the D25 ellipse of M101, of which ~24 are estimated to be background galaxies. Multiwavelength cross-correlations show that 20 sources are coincident with H II regions and/or supernova remnants (SNRs), seven have identified/candidate background galaxy counterparts, six are coincident with foreground stars and one has a radio counterpart.