The measurements of masses and luminosities of massive stars play an important role in understanding the formation and evolution of their host galaxies. In this work, we present the measurement of masses and luminosities of 2946 OB-type stars, including 78 O-type stars and 2868 B-type stars, based on their stellar parameters (effective temperature, surface gravity, and metallicity) and the Padova and Trieste Stellar Evolution Code isochrones model. Our results show that the median mass and luminosity of the 2946 OB-type stars are 5.4M_{sun}_ and log(L/L_{sun}_)=3.2 with median relative errors of 21.4% and 71.1%, respectively. A good agreement between our results estimated by using our method and those derived by using the orbital motions of binary stars from the literature is found for some B-type stars. In addition, we also fit the mass-luminosity relation of B-type stars by using our derived mass and the luminosity from Gaia Data Release 3.