Although previous searches for star clusters have been very successful, many clusters are likely still omitted, especially at high Galactic latitude regions. In this work, based on the astrometry of Gaia EDR3, we searched nearby (Parallax>0.8mas) all-sky regions, obtaining 886 star clusters, of which 270 candidates have not been cataloged before. At the same time, we have presented the physical parameters of the clusters by fitting theoretical isochrones to their optical magnitudes. More halo members and expanding structures in many star clusters were also found. Most of the new objects are young clusters that are less than 100 million years old. Our work greatly increased the sample size and physical parameters of star clusters in the solar neighborhood, in particular, 46 clusters are newly found with |b|>20deg, which represents an increase of nearly three fold of cluster numbers at high Galactic latitude regions.