We combine Sloan Digitital Sky Survey (SDSS) and WISE photometry for the full SDSS spectroscopic galaxy sample, creating spectral energy distributions (SEDs) that cover {lambda}=0.4-22{mu}m for an unprecedentedly large and comprehensive sample of 858365 present-epoch galaxies. Using MAGPHYS (da Cunha+ 2008MNRAS.388.1595D), we then simultaneously and consistently model both the attenuated stellar SED and the dust emission at 12 and 22{mu}m, producing robust new calibrations for monochromatic mid-IR star formation rate (SFR) proxies. These modeling results provide the first mid-IR-based view of the bimodality in star formation activity among galaxies, exhibiting the sequence of star-forming galaxies ("main sequence") with a slope of dlogSFR/dlogM_*_=0.80 and a scatter of 0.39dex. We find that these new SFRs along the SF main sequence are systematically lower by a factor of 1.4 than those derived from optical spectroscopy. We show that for most present-day galaxies, the 0.4-22{mu}m SED fits can exquisitely predict the fluxes measured by Herschel at much longer wavelengths. Our analysis also illustrates that the majority of stars in the present-day universe are formed in luminous galaxies (~L*) in and around the "green valley" of the color-luminosity plane. We make publicly available the matched photometry catalog and SED modeling results.