We present the X-ray source catalog for the Chandra monitoring observations of the elliptical galaxy, NGC 4649 (M60). The galaxy has been observed with Chandra ACIS-S3 in six separate pointings, reaching a total exposure of 299ks. There are 501 X-ray sources detected in the 0.3-8.0keV band in the merged observation or in one of the six individual observations; 399 sources are located within the D_25_ ellipse. The observed 0.3-8.0keV luminosities of these 501 sources range from 9.3x10^36^erg/s to 5.4x10^39^erg/s. The 90% detection completeness limit within the D_25_ ellipse is 5.5x10^37^erg/s. Based on the surface density of background active galactic nuclei (AGNs) and detection completeness, we expect ~45 background AGNs among the catalog sources (~15 within the D_25_ ellipse). There are nine sources with luminosities greater than 10^39^erg/s, which are candidates for ultraluminous X-ray sources. The nuclear source of NGC 4649 is a low-luminosity AGN, with an intrinsic 2.0-8.0keV X-ray luminosity of 1.5x10^38^erg/s. The X-ray colors suggest that the majority of the catalog sources are low-mass X-ray binaries (LMXBs). We find that 164 of the 501 X-ray sources show long-term variability, indicating that they are accreting compact objects. We discover four transient candidates and another four potential transients. We also identify 173 X-ray sources (141 within the D_25_ ellipse) that are associated with globular clusters (GCs) based on Hubble Space Telescope and ground-based data; these LMXBs tend to be hosted by red GCs. Although NGC 4649 has a much larger population of X-ray sources than the structurally similar early-type galaxies, NGC 3379 and NGC 4278, the X-ray source properties are comparable in all three systems.