We present constraints on cosmological parameters from the Pantheon+ analysis of 1701 light curves of 1550 distinct Type Ia supernovae (SNeIa) ranging in redshift from z=0.001 to 2.26. This work features an increased sample size from the addition of multiple cross-calibrated photometric systems of SNe covering an increased redshift span, and improved treatments of systematic uncertainties in comparison to the original Pantheon analysis, which together result in a factor of 2 improvement in cosmological constraining power. For a flat {Lambda}CDM model, we find {Omega}_M_=0.334+/-0.018 from SNe Ia alone. For a flat w_0_CDM model, we measure w_0_=-0.90+/-0.14 from SNeIa alone, H_0_=73.5+/-1.1km/s/Mpc when including the Cepheid host distances and covariance (SH0ES), and w_0_=-0.978_-0.031_^+0.024^ when combining the SN likelihood with Planck constraints from the cosmic microwave background (CMB) and baryon acoustic oscillations (BAO); both w_0_ values are consistent with a cosmological constant. We also present the most precise measurements to date on the evolution of dark energy in a flat w_0_w_a_CDM universe, and measure w_a_=-0.1_-2.0_^+0.9^ from Pantheon+ SNe Ia alone, H_0_=73.3+/-1.1km/s/Mpc when including SH0ES Cepheid distances, and w_a_=-0.65_-0.32_^+0.28^ when combining Pantheon+ SNe Ia with CMB and BAO data. Finally, we find that systematic uncertainties in the use of SNe Ia along the distance ladder comprise less than one-third of the total uncertainty in the measurement of H_0_ and cannot explain the present "Hubble tension" between local measurements and early universe predictions from the cosmological model.