This study is a part of the Cosmicflows-4 project with the aim of measuring the distances of more than ~10000 spiral galaxies in the local universe up to ~15000km/s. New HI line width information has come primarily from the Arecibo Legacy Fast ALFA Survey. Photometry of our sample galaxies has been carried out in optical (SDSS u, g, r, i, and z) and infrared (WISE W1 and W2) bands. Inclinations have been determined using an online graphical interface accessible to a collaboration of citizen scientists. Galaxy distances are measured based on the correlation between the rotation rate of spirals and their absolute luminosity, known as the Tully-Fisher relation (TFR). In this study, we present the calibration of the TFR using a subsample of ~600 spirals located in 20 galaxy clusters. Correlations among such observables as color, surface brightness, and relative HI content are explored in an attempt to reduce the scatter about the TFR with the goal of obtaining more accurate distances. A preliminary determination of the Hubble constant from the distances and velocities of the calibrator clusters is H0=76.0+/-1.1(stat.)+/-2.3(sys.)km/s/Mpc.