The emerging light from a galaxy is under the influence of its own interstellar medium, as well as its spatial orientation. Considering a sample of 2239 local spiral galaxies in optical (Sloan Digital Sky Survey u, g, r, i, and z) and infrared bands (WISE W1, W1), we study the dependency of the global intrinsic attenuation in spiral galaxies on their morphologies, sizes, and spatial inclinations. Reddening is minimal at the extremes of low mass and gas depletion and maximal in galaxies that are relatively massive and metal-rich and still retain substantial gas reserves. A principal component constructed from observables that monitor galaxy mass, relative H i content to old stars, and infrared surface brightness is strongly correlated with the amplitude of obscuration. We determine both a parametric model for dust obscuration and a nonparametric model based on the Gaussian process formalism. An average dust attenuation curve is derived for wavelengths between 0.36 and 4.5{mu}m.