Improving the capabilities of detecting faint X-ray sources is fundamental to increase the statistics on faint high-z AGN and star-forming galaxies. We performed a simultaneous Maximum Likelihood PSF fit in the [0.5-2]keV and [2-7]keV energy bands of the 4Ms Chandra Deep Field South (CDFS) data at the position of the 34930 CANDELS H-band selected galaxies. For each detected source we provide X-ray photometry and optical counterpart validation. We validated this technique by means of a raytracing simulation. We detected a total of 698 X-ray point-sources with a likelihood L>4.98 (i.e.> 2.7{sigma}). We show that the prior knowledge of a deep sample of Optical-NIR galaxies leads to a significant increase of the detection of faint (i.e. ~10^-17^cgs in the [0.5-2]keV band) sources with respect to "blind" X-ray detections. By including previous catalogs, this work increases the total number of X-ray sources detected in the 4Ms CDFS, CANDELS area to 793, which represents the largest sample of extremely faint X-ray sources assembled to date. Our results suggest that a large fraction of the optical counterparts of our X-ray sources determined by likelihood ratio actually coincides with the priors used for the source detection. Most of th e new detected sources are likely star-forming galaxies or faint absorbed AGN. We identified a few sources sources with putative photometric redshift z>4. Despite the low number statistics, this sample significantly increases the number of X-ray selected candidate high-z AGN.