We conduct a theoretical study on the ejection of runaway massive stars from R136 -the central massive, starburst cluster in the 30 Doradus complex of the Large Magellanic Cloud. Specifically, we investigate the possibility of the very massive star (VMS) VFTS 682 being a runaway member of R136. Recent observations of the above VMS, by virtue of its isolated location and its moderate peculiar motion, have raised the fundamental question of whether isolated massive star formation is indeed possible. We perform the first realistic N-body computations of fully mass-segregated R136-type star clusters in which all the massive stars are in primordial binary systems. These calculations confirm that the dynamical ejection of a VMS from an R136-like cluster, with kinematic properties similar to those of VFTS 682, is common. Hence, the conjecture of isolated massive star formation is unnecessary to account for this VMS. Our results are also quite consistent with the ejection of 30 Dor 016, another suspected runaway VMS from R136. We further note that during the clusters' evolution, mergers of massive binaries produce a few single stars per cluster with masses significantly exceeding the canonical upper limit of 150 M_{sun}_. The observations of such single super-canonical stars in R136, therefore, do not imply an initial mass function with an upper limit greatly exceeding the accepted canonical 150M_{sun}_limit, as has been suggested recently, and they are consistent with the canonical upper limit.