We present the initial results from the Spitzer Survey of the Small Magellanic Cloud (S^3^MC), which imaged the star-forming body of the SMC in all seven MIPS and IRAC wave bands. We find that the F8/F24 ratio (an estimate of PAH abundance) has large spatial variations and takes a wide range of values that are unrelated to metallicity but anticorrelated with 24um brightness and F24/F70 ratio. This suggests that photodestruction is primarily responsible for the low abundance of PAHs observed in star-forming low-metallicity galaxies. We use the S^3^MC images to compile a photometric catalog of 400000 mid- and far-infrared point sources in the SMC.