SDSS repeat spectroscopic observations have resulted in multiepoch spectroscopy for 2500 quasars observed more than 50 days apart. From this sample, calibrating against stars observed simultaneously, we identify 315 quasars that have varied significantly between observations (with respect to assumed nonvariable stars observed concurrently). These variable quasars range in redshift from 0.5 to 4.72. This is the first large quasar sample studied spectroscopically for variability and represents a potentially useful sample for future high-redshift reverberation mapping studies. This also marks the first time the precise wavelength dependence of quasar variability has been determined, allowing both the continuum and emission-line variability to be studied.