In the course of a program to digitize the astronomical plates of the Sternberg Astronomical Institute's plate stacks, we are developing algorithms for searching for new variable stars and studying them using digitized photographic plates. We have discovered and studied 480 new variable stars in a 10{deg}x10{deg} field of view centered on 66 Ophiuchi. The digitized plate negatives used are from the 40-cm astrograph, and are 30x30cm in size. These stars include three new Cepheids of the Galaxy's spherical component, 157 eclipsing binaries, 11 high-amplitude {delta} Scuti stars (HADSs), 144 RR Lyrae stars, 110 irregular variables (109 LB and one white star), and 55 semi-regular red variables.