The results of speckle interferometric observations at the 4.1 m Southern Astrophysical Research Telescope (SOAR) in 2018 are given, totaling 3097 measurements of 2427 resolved pairs with separations from 11 mas to 5.9" (median 0.15", magnitude difference up to 7 mag) and nonresolutions of 624 targets. This work continues our long-term speckle program. Its main goal is to monitor orbital motion of close binaries, including members of high-order hierarchies and Hipparcos pairs in the solar neighborhood. Also, pre-main-sequence stars in the Orion OB1 association were surveyed, resolving 26 out of 118 targets. In addition, we report the discovery of 35 new companions among field visual multiples (some of which are likely optical) and first-time resolutions of another 31 pairs. By combining the measurements given here with the published ones, we computed 76 orbits for the first time and updated orbital elements of 34 visual binaries. Their periods range from 0.65 to 1100 yr, and their quality varies from first tentative solutions of grade 5 to accurate elements of grades 1 and 2. Finally, a list of 53 spurious pairs discovered by various techniques and unresolved at SOAR is given.