Two hundred forty-two members of the Praesepe and alpha Persei clusters have been surveyed with high angular resolution 2.2{mu}m speckle imaging on the 3m Infrared Telescope Facility, the 5m Hale, and the 10m Keck telescopes, along with direct imaging using the near-infrared camera (NICMOS) aboard the Hubble Space Telescope. The observed stars range in spectral type from B (~5M_{sun}_) to early M (~0.5M_{sun}_), with the majority of the targets more massive than ~0.8M_{sun}_. The one quadruple and 39 binary systems detected encompass separations from 0.053" to 7.28"; 28 of the systems are new detections, and there are nine candidate substellar companions.