We present new VLT/MUSE mosaic observations of a 3x8 arcmin^2^ area along the southern major axis of the nearby galaxy M33 at a distance of 840kpc from the Milky Way. These data provide an unprecedented view of the galaxy interstellar medium (ISM), and allow us to resolve ionised nebulae at a spatial scale of ~=5pc. We identify and catalogue 124 HII regions, down to H{alpha} luminosities of ~=5*10^35^erg/s, one order of magnitude fainter than previous surveys on local galaxies, and compare these regions with the spatial distribution of ionising stars and embedded star clusters. For each region, we extract the corresponding integrated optical spectra and measured the intensity of key optical emission lines (H{beta}{lambda}4861, [OIII]4959,5007, [NII]{lambda}6548,6584, H{alpha}, [SII]{lambda}6716,6731, [SIII]{lambda}9069, other weaker optical lines when detectable, and Paschen lines) to characterize their physical properties of the ioinized gas such as density, dust attenuation, and metallicity. Our spatially resolved line ratio and flux maps reveal remarkable diversity in ionisation properties, from dust-obscured regions hosting young stellar objects to highly ionised bubbles exhibiting high [OIII]/H{beta} ratios (>5). Our data reveal a diversity of ionisation fronts, ranging from well-defined to partial to absent. Radial profiles indicate the presence of both optically thin (density-bounded) and optically thick (radiation-bounded) HII regions. Our study highlights the richness of this MUSE mosaic and their unparalleled view of the ISM. In particular, the ability to probe the ISM at ~=5pc resolution opens a new window onto the complex structure of the ionised gas, enabling direct insight into how stellar feedback operates on the scales where it originates.