Time-resolved Fourier transform infrared emission spectroscopy, Fourier transform absorption infrared spectroscopy, and high-resolution UV-ViS emission spectroscopy have been exploited in order to characterize the chemistry of isocyanic acid (HNCO) under glow discharge conditions in planetary atmospheres. HNCO mixtures (i.e., composed of di-hydrogen or ammonia) have been investigated in order to unveil the possible reaction pathways leading to the synthesis of the key prebiotic molecule formamide (HCONH_2_), upon planetary atmospheres containing isocyanic acid in presence of di-hydrogen and, separately, of ammonia. In addition, ab initio Molecular Dynamics simulations coupled with a state-of-the-art metadynamics technique have been performed in order to identify the most likely chemical pathways connecting HNCO to formamide. It turned out that the direct hydrogenation of HNCO is thermodynamically favored. Incidentally, also the experimental results - supplied by a simplified kinetic model - proved the favorability of the reaction HNCO + H_2_ -> HCONH_2_ which, moreover, spontaneously takes place in unbiased ab initio Molecular Dynamics simulations carried out under the effect of intense electric fields.