We present the compilation and properties of a meta-catalogue of X-ray detected clusters of galaxies, the MCXC. This very large catalogue is based on publicly available ROSAT All Sky Survey-based (NORAS, REFLEX, BCS, SGP, NEP, MACS, and CIZA) and serendipitous (160SD, 400SD, SHARC, WARPS, and EMSS) cluster catalogues. Data have been systematically homogenised to an overdensity of 500, and duplicate entries from overlaps between the survey areas of the individual input catalogues are carefully handled. The MCXC comprises 1743 clusters with virtually no duplicate entries. For each cluster the MCXC provides three identifiers, a redshift, coordinates, membership in the original catalogue, and standardised 0.1-2.4keV band luminosity L_500_, total mass M_500_, and radius R_500_. The meta-catalogue additionally furnishes information on overlaps between the input catalogues and the luminosity ratios when measurements from different surveys are available, and gives notes on individual objects.