Table 1 contents 845 simultaneous measurements collected in each of the four uvby colours of the Stromgren photometric system for the Gamma Doradus variable HD 218427. The data are magnitude differences (Du, Dv, Db, Dy, D(b-y), Dm1, Dc1) of the variable star minus comparison star in the standard system versus Heliocentric Julian Date. The comparison star is HD 219874. The origin in time is the Julian Day 2452839. The observations were carried out by the authors through the year 2003 using the 0.90m telescope at Sierra Nevada Observatory, Spain (Julian Days:0 to 69 in the table) and the 1.50m telescope at San Pedro Martir Observatory, Mexico (Julian Days: 122 to 128). Both telescopes are equipped with identical six-channel uvby-Hbeta spectrograph photometers for simultaneous measurements in uvby or in the narrow and wide H{beta} channels, respectively. Please note that a technical problem arose with the "u" filter in the 1.50m telescope, which made the "u" data collected with that telescope useless and they are named as 99.