The present paper investigates the properties of the dust mass loss in stars populating the giant branch of the globular cluster 47 Tuc, by combining ISOCAM and DENIS data. Raster maps of 5 fields covering areas ranging from 4x4 to 15x15arcmin^2^ at different distances from the center of the cluster have been obtained with ISOCAM at 11.5{mu}m (LW10 filter). The covered fields include most of the red variables known in this cluster. A detection threshold of about 0.2 mJy is achieved, allowing us to detect giant stars at 11.5{mu}m all the way down to the horizontal branch. No dust-enshrouded asymptotic giant branch stars have been found in the observed fields, contrary to the situation encountered in LMC/SMC globular clusters with larger turnoff masses. The color index [12]-[2] (based on the ISO 11.5{mu}m flux and on the DENIS K_S_ magnitude) is used as a diagnostic of dust emission (and hence dust mass loss). Its evolution with luminosity along the giant branch reveals that dust mass loss is only present in V3 (the only cluster Mira variable observed in the present study) and in V18, a star presenting intermittent variability. This conclusion confirms the importance of stellar pulsations in the dust formation and ensuing mass loss.