The catalogue of radial velocities of Galactic stars with high precision astrometric data, 2nd version (CRVAD-2), is the result of a merging of star lists from the All-Sky Compiled Catalogue of 2.5 Million Stars (ASCC-2.5, Cat. I/280) with the General Catalogue of Radial Velocities (GCRV, Cat. III/213) and with other recently published radial velocity lists and catalogues. Cross identification of objects was carried out with help of coordinate, magnitude, colour and/or spectral type criteria. Data from the Catalogue of Components of Double and Multiple Stars (CCDM, Cat. I/274) were taken into account for the identification of multiple system components. Altogether 54907 stars from the ASCC-2.5 were identified with 51762 stars from the RV source catalogues, 3085 stars have secondary components and 30 stars have 3rd components in multiple systems. The CRVAD-2 includes accurate J2000 equatorial coordinates, proper motions and trigonometric parallaxes in the Hipparcos system, Johnson's BV photometric data, spectral types, radial velocities, multiplicity and variability flags. Stars are sorted in the order of increasing right ascension J2000. This catalogue supersedes the previous version numbered <III/239>.