This is a catalog of some 250,000 well-confirmed infrared point sources observed by the Infrared Astronomical Satellite, i.e., sources with angular extents less than approximately 0.5, 0.5, 1.0, and 2.0 arcmin in the in-scan direction at 12, 25, 60, and 100 microns, respectively. Positions, flux densities, uncertainties, associations with known astronomical objects and various cautionary flags are given for each object. While two other complementary data sets - the Working Survey Data Base and a file of rejected sources - give information about point-like sources, the information available in the Point Source Catalog should satisfy almost all users. Away from confused regions of the sky, the survey is complete to about 0.4, 0.5, 0.6, and 1.0 Jy at 12, 25, 60, and 100 microns. Typical position uncertainties are about 2 to 6 arcseconds in-scan and about 8 to 16 arcseconds cross-scan. The processing steps applied to detect and confirm point sources, and the positional and photometric error analyses are described in the IRAS Catalogs and Atlases Explanatory Supplement; the catalog format is described in Chapter X. The sources appear in order of increasing (1950.0) right ascension. The included script "tofits.sh" should generate the FITS version of the tables on Unix platforms.